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KMID : 0385020030190040235
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Korean Journal of Laboratory Animal Science
2003 Volume.19 No. 4 p.235 ~ p.239
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Comparative evaluation on the therapeutic effect and withdrawal reversing phenomenon of GODEX(R) in hepatotoxicity induced by carbon tetrachloride plus ethanol
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Sin Ji-Soon
Jung Eun-Young
Chai Hee-Youl
Kwon Woon
Choi Ehn-Kyoung
Cho Young-Min
Hwang Seock-Yeon
Lee Min-Ho
Kim Yun-Bae
Kang Jong-Koo
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Abstract
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The protective activity of GODEX® (Hepadif® plus dimethyl diphenyl bicarboxylate [DDB]) against liver injury induced by ethanol plus carbon tetrachloride(CCl4) was investigated in rats. During feeding with ethanol (10%) in drinking water, the animals were orally administered with a high dose (1 ml/kg) of CCl4, followed by repeated low doses (0.5 ml/kg) 3, 7, 10 and 14 days after the 1st administration. The drugs, Hepadif® (250 mg/kg), DDB (30 mg/kg) or their combinational formula GODEX® (250 mg/ kg), were orally treated on days 10, 11, 12, 14 and 17. The reversed increase in serum aspartate transaminase (AST) and alanine transaminase (ALT) levels on 2 days following withdrawal of drug administration after 4-times treatment was very much low in GODEX®-treated rats, although Hepadif® and DDB also exerted effectiveness to some extent. In addition, the rats treated with GODEX® exhibited relatively mild histopathological changes compared with the animals given Hepadif® or DDB. Taken together, it is proposed that the hepato-protective potential of GODEX®, leading to a low withdrawal recurrence of hepatic injuries, is superior to those of Hepadif® or DDB.
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KEYWORD
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GODEX(R), Hepatoprotection, CCl4, Ethanol, Withdrawal recurrence
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